nsclc cells — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6823	E3330		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
	E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
T21312	Afatinib	Afatinib free base,BIBW 2992	EGFR , Autophagy
	Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively).		EGFR , Autophagy
T1773	Afatinib Dimaleate	BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate	EGFR , HER , Autophagy
	Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act...		EGFR , HER , Autophagy
T3181	SW044248		Topoisomerase
	SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.		Topoisomerase
T36404L	PRLX-93936 HCL	PRLX-93936 hcl(903499-49-0 Free base)	Ferroptosis , Reactive Oxygen Species
	PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.		Ferroptosis , Reactive Oxygen Species
T72043	SCFSkp2-IN-2		Apoptosis , E1/E2/E3 Enzyme
	SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells.		Apoptosis , E1/E2/E3 Enzyme
T9460	IMDK		PI3K
	iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors withou...		PI3K
T76873	Nidanilimab	CAN04	IL Receptor
	Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. Nidanilimab has antitumor activity, cutting off the IL1α and IL1β signaling pathways and inducing the immune system to destr...		IL Receptor
T4605	NT157		IGF-1R , STAT
	NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.		IGF-1R , STAT
T61627	IMDK quarterhydrate
	iMDK quarterhydrate, a potent PI3K inhibitor, is effective in inhibiting the growth factor MDK (also known as midkine or MK) while demonstrating suppression of non-small cell lung cancer (NSCLC). In combination with a ME...
T31566	Doranidazole	PR-350,PR350,PR-000350,RP-343,PR000350
	Dornidazole (PR-000350, PR-350, RP-343, PR-69) is an effective radiosensitizer for hypoxic cells with the potential for the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer.
T63528	HSP90-IN-11
	HSP90-IN-11 is a potent inhibitor of HSP90 and induces significant accumulation of the sub-G1 population. HSP90-IN-11 has a potent HSP90α inhibitory effect comparable to that of AUY-922 (Luminespib). In CRC and NSCLC cel...
T81132	Soladulcoside A
	Soladulcoside A, a steroidal glycoside with antineoplastic properties, is derived from the entire Solanum nigrum plant. It demonstrates inhibitory effects on A549 cells, suggesting its applicability in researching non-sm...
T63830	Anticancer agent 76
	Anticancer agent 76 (Compound CT2-3) is an anti-cancer agent that significantly inhibits proliferation, induces cell cycle arrest, ROS production and apoptosis in human NSCLC cells.
TN1642	Ferruginol		BCL , PARP , Caspase
	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells.		BCL , PARP , Caspase
T38978	CYH33
	CYH33, an orally active and highly selective PI3Kα inhibitor, demonstrates specificity with IC50 values of 5.9 nM for the α isoform, 598 nM for β, 78.7 nM for δ, and 225 nM for γ. It effectively inhibits Akt and ERK phos...
T78751	DG1
	DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressing the expression of CD26, ET-1, FGF-1, and EGF. Additionally,...
T74982	Akt3 degrader 1
	Akt3 Degrader 1 (compound 12l), a selective Akt3 degrader, effectively overcomes Osimertinib-induced resistance in H1975OR NSCLC cells. Besides its role in overcoming drug resistance, it exhibits anti-proliferative prope...
T38979	CYH33 methanesulfonate	CYH33 methanesulfonate
	CYH33 methanesulfonate is a highly selective and orally active inhibitor of PI3Kα, with IC50 values of 5.9 nM, 598 nM, 78.7 nM, and 225 nM against the α, β, δ, and γ isoforms, respectively. This compound effectively inhi...
T35895	Ingenol 3,20-dibenzoate
	Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms. It effectively induces the translocation of nPKC-delta, -epsilon, and -theta as well as PKC-mu from the cytosolic fraction to the partic...